SYNSEPALUM DULCIFICUM [MIRACLE FRUIT]A COMPREHENSIVE REVIEW OF BIOACTIVECOMPOUNDS, TASTE-MODIFYING MECHANISMS, ANDTHERAPEUTIC APPLICATIONS IN CLINICAL NUTRITION

Abstract

Synsepalum dulcificum, commonly known as miracle fruit, is a West African plant renowned for its unique taste-modifying properties attributed to the glycoprotein miraculin. By temporarily altering taste perception, specifically
converting sour tastes into sweet. S. dulcificum has gained attention not only as a novelty but as a promising candidate in clinical nutrition and therapeutic applications. This review provides a comprehensive synthesis of current scientific and clinical evidence surrounding the potential health benefits and applications of S. dulcificum. The fruit’s phytochemical pro-file includes antioxidants, flavonoids, and polyphenols, which contribute to its proposed anti-inflammatory, antihyperglycemic, and lipid-lowering effects. Recent studies have explored its role in managing chemotherapy-induced taste disturbances [dysgeusia], aiding glycemic control in diabetic patients, and supporting weight management in obesity. Its potential to improve appetite and nutritional intake in patients undergoing cancer treatment or suffering from metabolic disorders highlights its relevance in clinical nutrition. While preclinical studies show promising pharmacological activity, human trials remain limited, with variability in study design and outcomes. This review critically examines the available literature, discussing mechanisms of action, therapeutic efficacy, safety profile, and potential for integration into functional foods or medical nutrition therapy. Overall, S. dulcificum represents a novel, natural agent with emerging clinical relevance. However, further well-designed, large-scale clinical trials are necessary to validate its efficacy and ensure safe application in medical practice. This review aims to guide future research and support healthcare professionals considering S. dulcificum in nutritional and therapeutic interventions.