National Journal of Medical Research and Yoga Sciences (NJMRYS)
NJMRYS is a peer-reviewed, open-access journal publishing multidisciplinary research in medical sciences, yoga sciences, and allied health fields, promoting ethical and evidence-based scholarly communication. National Journal of Medical Research & Yoga Sciences (NJMRYS) is a peer-reviewed, open-access multidisciplinary journal that publishes original and evidence-based research in medical sciences, yoga sciences, and allied health disciplines. The journal provides an academic platform for clinicians, researchers, educators, and healthcare professionals to share scientific knowledge that supports integrative and holistic approaches to health and disease management. NJMRYS follows ethical publishing standards and a rigorous peer-review process to ensure the quality, originality, and relevance of published articles, with the objective of advancing medical education, research, and healthcare practice at national and international levels. The National Journal of Medical Research & Yoga Sciences (NJMRYS) is a peer-reviewed, open-access, multidisciplinary scholarly journal devoted to the dissemination of high-quality research in medical sciences, yoga sciences, and allied health disciplines. Established in 2015, the journal aims to serve as an academic bridge between modern biomedical research and traditional, complementary, and integrative approaches to health and disease management. NJMRYS publishes a wide range of article types, including original research articles, review articles, systematic reviews, meta-analyses, case reports, short communications, technical notes, and clinical or educational perspectives. The journal encourages interdisciplinary and translational research that contributes to preventive healthcare, clinical practice, public health, yoga therapy, rehabilitation sciences, and medical education. The journal follows a rigorous double-blind peer-review process to ensure scientific accuracy, originality, and relevance. All submissions are evaluated for ethical compliance, methodological soundness, and academic merit in accordance with internationally accepted editorial and publication ethics guidelines. NJMRYS supports transparency, responsible authorship, and integrity in scholarly communication. Published by An International Multidisciplinary Research Publishers, NJMRYS provides free and unrestricted access to its published content, facilitating the global exchange of knowledge. By promoting national and international collaboration among researchers, academicians, and healthcare professionals, the journal strives to advance evidence-based medicine, integrative health sciences, and holistic well-being. Editorial Team NJMRYS www.njmrys.com
REVISITING PHYSIOLOGICAL PLASTICITY AN UNDEREXPLORED DETERMINANT OF HEALTH AND DISEASE
Physiological plasticity refers to the capacity of cells, tissues, and organ systems to adapt structurally and functionally in response to internal and external stimuli. While plasticity is well recognized in developmental biology and neurophysiology, its broader relevance across adult physiological systems remains underexplored. This editorial highlights physiological plasticity as a unifying concept linking adaptation, resilience, and disease susceptibility. Recognizing plasticity as a core physiological principle may offer new insights into disease prevention, recovery, and personalized medicine.
Copyright (c) 2026 National Journal of Medical Research and Yoga Sciences (NJMRYS) https://creativecommons.org/licenses/by-nc-sa/4.0
EFFECT OF PRANAYAMA ON AUTONOMIC NERVOUS SYSTEM REGULATION: A PHYSIOLOGICAL INSIGHT
Background: Autonomic imbalance characterized by sympathetic overactivity and reduced parasympathetic tone is implicated in hypertension, anxiety disorders, and cardiovascular morbidity. Yogic breathing techniques (pranayama) are increasingly recognized for their modulatory effects on autonomic function. Objective: To highlight the physiological mechanisms through which pranayama influences autonomic regulation and its potential clinical implications. Methods: A narrative review of published physiological and clinical studies examining the impact of pranayama on heart rate variability (HRV), blood pressure, respiratory parameters, and neuroendocrine responses was conducted. Results: Evidence suggests that slow and controlled breathing techniques enhance vagal tone, improve HRV indices, reduce sympathetic discharge, and lower systolic and diastolic blood pressure. Studies demonstrate improved baroreflex sensitivity and decreased plasma cortisol levels following regular practice. Respiratory efficiency parameters such as forced vital capacity and peak expiratory low rate also show significant improvement. Conclusion: Pranayama serves as a non-pharmacological intervention capable of restoring autonomic balance. Its integration into preventive and therapeutic strategies for stress-related and cardiovascular disorders is supported by physiological evidence, though large-scale randomized controlled trials are warranted.
PHYSIOLOGICAL BASIS AND HEALTH BENEFITS OF YOGA
Background: Yoga is an ancient mind–body discipline increasingly supported by modern physiological research. Evidence suggests signi icant effects on autonomic balance, cardiovascular regulation, respiratory ef iciency, and neuroendocrine stress pathways. Methods: A narrative review of peer-reviewed literature was conducted focusing on clinical and experi mental studies evaluating physiological parameters in luenced by yoga practices, including asanas, pranayama, and medita tion. Results: Yoga practice is associated with enhanced parasympathetic activity, improved heart rate variability, reduced blood pressure, improved pulmonary function, and decreased stress biomarkers including cortisol. Neurotransmitter mod ulation such as increased GABA activity has also been reported. Conclusion: Yoga exerts measurable systemic physiological effects primarily through autonomic modulation and neuroendocrine regulation. It represents a safe and cost-effective ad junct in preventive and lifestyle medicine.
Copyright (c) 2025 National Journal of Medical Research and Yoga Sciences (NJMRYS) https://creativecommons.org/licenses/by-nc-sa/4.0
IMPACT OF PRE-ENRICHMENT CULTURE TECHNIQUES ON THE RECOVERY OF BACTERIAL PATHOGENS FROM CLINICAL SPECIMENS
Background: Isolation of bacterial pathogens from clinical specimens is a fundamental requirement in diagnostic microbiology. However, conventional direct culture techniques may fail to detect pathogens when organisms are present in low numbers or when specimens contain inhibitory substances. Pre-enrichment culture techniques are designed to enhance bacterial recovery prior to inoculation onto solid media. Objective: To evaluate the effectiveness of pre-enrichment culture techniques in improving the isolation of bacterial pathogens from routine clinical specimens. Materials and Methods: A prospective analytical study was conducted on 120 clinical specimens. Each specimen was processed by direct culture on solid media and by pre-enrichment in liquid media followed by subculture. Isolation rates, specimen-wise yield, Gram staining quality, and organism proiles were compared. Results: Pre-enrichment culture demonstrated a higher isolation rate [79.2%] compared to direct culture [55.8%]. Improved Gram-staining clarity and well-defined colony morphology were observed following enrichment, particularly in sterile body fluids and tissue samples. Conclusion: Pre-enrichment culture significantly enhances bacterial detection from clinical specimens and should be routinely employed to improve diagnostic sensitivity in microbiology laboratories.
SIGNIFICANCE OF LIQUID MEDIA IN MEDICAL MICROBIOLOGY
Background: Isolation of pathogenic microorganisms remains fundamental to the diagnosis and management of infectious diseases. Direct inoculation of clinical specimens onto solid media may yield false-negative results when the bacterial load is low or when inhibitory substances are present. Liquid media act as enrichment systems that enhance microbial recovery. Aim: To evaluate the role of liquid media in improving bacterial isolation from clinical specimens compared with direct inoculation onto solid media. Materials and Methods: A prospective comparative study was conducted on 100 clinical specimens. Each specimen was processed by direct inoculation onto solid media and by enrichment in liquid media fol lowed by subculture. Culture positivity, Gram-staining quality, colony morphology, and organism distribution were analyzed. Results: Liquid media enrichment demonstrated a higher culture positivity rate (82%) compared with direct inocu lation (58%). Enriched cultures showed improved Gram-staining clarity and well-de ined colony morphology. Conclusion: Liquid media signi icantly enhance bacterial isolation and diagnostic accuracy and should be routinely incorporated into diagnostic microbiology work lows.
A STUDY ON CLINICAL UTILITY OF COCCUS CACTI
Background: Coccus cacti is a well known homoeopathic remedy for its marked action on various systems especially in conditions characterized by thick, ropy, teanious expectoration. Aims And Objectives : To Study the clinical utility of Coccus cacti in day to day homoeopathic practice. Materials And Methods:30 cases were taken up for the study from JSPS Govt. Homoeopathic Medical College And Hospital for 2yrs. Results: The study observed clinical improvement in acute and chronic diseases. The af inity of Coccus cacti and its detailed symptomatology were studied. Conclusion: Coccus cacti is an effective remedy, and the chief action is on respiratory related disorders mainly on Bronchial asthma which correlated with the literature.
primary action on the respiratory system
PRECLINICAL INDICATORS AND DIAGNOSTIC APPROACHES TO MYOCARDIAL INFARCTION IN YOUNG ADULTS-ORIGINAL ARTICLE
Background: Myocardial infarction (MI) in young adults is increasingly recognized as a major public health concern. Unlike older populations, MI in young adults often arises from a complex interplay of traditional and non-traditional risk factors and may remain clinically silent until an acute event occurs. Objective: This review aims to summarize the preclinical indicators, underlying pathophysiological mechanisms, and current diagnostic approaches relevant to early identiication of myocardial infarction risk in young adults. Methods: A narrative review of published literature focusing on myocardial infarction in individuals aged 18–45 years was conducted. Studies addressing pathophysiology, risk factors, screening tools, and diagnostic strategies were analyzed. Results: Preclinical indicators such as endothelial dysfunction, autonomic imbalance, subclinical atherosclerosis, inflammatory biomarkers, and genetic predisposition play a critical role in the early development of myocardial infarction in young adults. Diagnostic tools including electrocardiography, biochemical markers, imaging modalities, and risk stratification models aid in early detection, though their routine use in asymptomatic individuals remains debated. Conclusion: Early recognition of preclinical indicators combined with targeted diagnostic strategies can improve risk stratification and prevention of myocardial infarction in young adults. Incorporating physiology-based screening approaches may reduce morbidity and mortality in this population.
ULTRASOUND EVALUATION OF MUSCLE ARCHITECTURE IN CHILDREN WITH MUSCULAR DYSTROPHY A COMPREHENSIVE REVIEW
Muscular dystrophies are a heterogeneous group of inherited neuromuscular disorders characterized by progressive muscle weakness and degeneration. Early diagnosis and continuous monitoring are essential for optimizing clinical management, especially in children. Muscle ultrasound has emerged as a valuable, non-invasive imaging modality for evaluating muscle architecture and pathology. This review provides a comprehensive overview of the role of ultrasound in assessing muscle architecture in pediatric muscular dystrophy, including principles of imaging, normal and pathological muscle characteristics, disease-specific ultrasound findings, quantitative techniques, advantages, limitations, and future perspectives. The growing use of ultrasound offers significant potential for early diagnosis, disease monitoring, and assessment of therapeutic response in children with muscular dystrophy.
NEONATAL HYPOTHERMIA AND ITS IMPACT ON EARLY MORBIDITY AND MORTALITY AN OBSERVATIONAL STUDY
Background: Neonatal hypothermia is a frequent and preventable condition that signicantly contributes to early neonatal morbidity and mortality, particularly in low- and middle-income countries. Objectives: To assess the prevalence of neonatal hypothermia at admission, identify associated risk factors, and evaluate its impact on early morbidity and mortality. Materials and Methods: This hospital-based observational study was conducted in the neonatal unit of a tertiary care hospital. All live-born neonates admitted within 24 hours of birth during the study period were included. Axillary temperature was recorded at admission and classified according to World Health Organization [WHO] criteria. Maternal and neonatal characteristics, early neonatal morbidities, and mortality were documented and analyzed. Results: A total of 200 neonates were included in the study. Hypothermia at admission was observed in 118 [59%] neonates. Preterm birth, low birth weight, and outborn delivery were significantly associated with hypothermia. Hypothermic neonates had higher incidences of sepsis, respiratory distress, hypoglycemia, and significantly higher early neonatal mortality compared to normothermic neonates. Conclusion: Neonatal hypothermia is common and is strongly associated with increased early morbidity and mortality. Strict adherence to thermal care practices from birth through transport and hospitalization is essential to improve neonatal outcomes.
PHYSIOLOGY IN THE MODERN ERA INTEGRATING CORE SCIENCE WITH CLINICAL AND PREVENTIVE HEALTH
Background: Physiology forms the foundation of all medical sciences and remains central to understanding health, disease, and therapeutic interventions. As the study of normal functions of the human body, physiology provides the framework upon which clinical medicine, diagnostics, and preventive healthcare are built. Despite rapid technological advancements and increasing specialization in medicine, the importance of physiology has not diminished; rather, it has expanded in scope and relevance.
CHRONIC INFLAMMATORY DISEASE- PSORIASIS ITS DIET MANAGEMENT AND PREVENTION
Is a long-term (chronic) skin problem that causes skin cells to grow too quickly, resulting in thick, white, silvery, or red patches of skin. Psoriasis isn't contagious. It can't be spread by touch from person to person. Normally, skin cells grow gradually and flake off about every 4 weeks. New skin cells grow to replace the outer layers of the skin as they shed. But in psoriasis , new skin cells move rapidly to the surface of the skin in days rather than weeks. They build up and form thick patches called plaques .The patches range in size from small to large.
HYPOKALEMIA IS A LOWER THAN NORMAL AMOUNT OF POTASSIUM INTHE BLOOD IT MAY RESULT FROM A NUMBER OF CONDITIONS
Potassium is needed for cells, especially nerve and muscle cells, to function properly. You get potassium through food. The kidneys remove excess potassium in the urine to keep a proper balance of the mineral in the body. Hypokalemia is a metabolic disorder that occurs when the level of potassium in the blood drops too low.
THE STUDY OF HYPOKALEMIA AND HYPERKALEMIA IN VARIOUS DISEASES
Fluid & Electrolytes imbalance is often observed in many disease conditions particularly in hospitalized patients. Potassium is one of the important electrolytes; alteration of serum levels (Hypokalemia & Hyperkalemia) will lead to various metabolic complications witch may be fatal. Early diagnosis will help in the treatment & overall management. This will help in reducing the morbidity & mortality. In this background we tried to enumerate, the causes of hypokalemia & hyperkalemia in the patients admitted in various Dept. of Mamata General Hospital, Khammam.
STUDY ON GLYCEMIC STATUS IN SIBLINGS OF DIABETIC PARENTS
Introduction: As per Indian council of medical research survey, incidence of diabetes in 1975 was around 2.1% which increased to 4.5% by 1990 and with the present trend is likely to reach around 6.8% in this millennium. Offspring of patients with Non insulin depended diabetes mellitus have a 40-60% chance of developing type 2 diabetes and increased frequency of impaired glucose tolerance. The siblings of diabetic parents are at high risk than siblings of non diabetic parents. The glycemic status plays a crucial role and it is a good indicator to alert the offspring’s of diabetic parents. Materials & Methods: The study was carried in department of Biochemistry on 30 control cases (23 Males 07 Females) of siblings of non diabetic parents (Group I) and 60 cases (42 Males, 18 Females) of siblings of diabetic parents (Group II) of same aged group. The glycemic status of both groups is studied by estimating the Glucose tolerance test and glycated haemoglobin. Results: Siblings of diabetic parents were further divided into two groups, normal glucose tolerance group and impaired glucose tolerance group. The Body mass index, fasting blood glucose, peak blood glucose and glycated haemoglobin levels were shown significant difference in siblings of diabetic parents with impaired glucose tolerance.
Single Stage Global Fusion for Fracture Subluxation of Cervical Spine Injury-Case Report
Introduction: Fracture subluxation following cervical spine injury is commonly encountered. Fracture subluxation can result in a serious spinal injury due to compression of the spinal cord. Though decompression of spine is done either anterior or posterior depending upon the site of compression, there is no consensus regarding the stabilization of spine either anterior or posterior or both after decompression of the spinal cord. Global fusion involves combined anterior and posterior stabilization of cervical spine. We report a case of fracture subluxation of C6 over C7 vertebra for whom global fusion was done in a single stage to prevent neurological deficit. Materials: Thirty six year old male patient who was a construction worker was brought to casualty after history of fall from height of 20 feet. Patient was immediately immobilized with Philadelphia collar and examined clinically for neurological deficits. On examination patient had no motor weakness and had hypoesthesia in C8 dermatome bilaterally. Radiological examination was done and patient was taken up for surgery. Global fusion following decompression was done for the patient. Results: Anterior decompression with bone grafting and anterior cervical plate fixation followed by posterior stabilization with interspinous wiring and bone grafting was done. Postoperative period was uneventful. Patient recovered from hypoesthesia and immediate mobilization was started. Conclusion: The combined single-stage anterior and posterior stabilization procedure represents a viable option in the treatment of patients with fracture subluxation following cervical spine injury than with single anterior or posterior approach alone.
Oxytocin was discovered by the great Italian scientist Nicholas Farraye in the year1835. Apart from the well-known function of uterine contraction and milk ejection, it is said to play a significant role in creating an effective bond between mother and child, in trusting people, maintain eye to eye contact during a conversation. Pitocin and Syntocin are the commonly used drugs, the chemical similarity to Oxytocin makes them an ideal choice of drug for various cases for example at the time if parturition. Oxytocin is a potent molecule with a unique and unusually broad profile of biological and behavioral effects. Oxytocin acts upon receptors and tissues that are ancient and have evolved many functions. Hence, in this review we discussed the pharmacological role of Oxytocin, social effects of Oxytocin in humans, Oxytocin pathways and evolution of human behaviour, the chemistry of love and neurobiology of love.
Effect of Refractive error on VEP in Myopic Boys and Girls
Introduction: Visual evoked potentials (VEPs) are summated electrical signals generated by occipital regions of the Cortex in response to visual stimuli & recorded from human scalp. It tests the function of visual pathway from retina to occipital cortex and more sensitive to changes in the visual stimuli. It is very useful when causes of poor vision are uncertain. VEP amplitude and latencies are affected by multiple variables like age, gender, eye dominance, eye movement, visual acuity and refractive errors. To determine the influence of refractive error on VEP this study was done in myopic boys and girls. Methods: 40 controls, 17 boys, 23 girls were selected.40 myopic subjects, 17 boys, 23 girls with refractive error in a range of 1to 8.5 Dioptres were participated. All were aged between 17-21.Refractive error was measured by auto refractometry. VEPs were performed by checkerboard reversal stimuli system. Results: Statistical analysis showed significant prolongation of P100 latency [P100L] in myopic subjects with a P value of < 0.0001. Reduction in P100 amplitude was found and it was significant at P< 0.1 .The results were also compared separately for boys and girls.P100L was significant with a P value of < 0.0001 for boys and it was significant with a P value of 0.0007 for girls. With regard to amplitude, reduction in amplitude was observed with a significant P value of 0.0369 for boys and insignificant reduction in amplitude with a P value of 0.4103 for girls. Pearson's correlation study revealed negative correlation for VEP-L and weak positive correlation for VEP-amplitude. Conclusion: During VEP recording, the subject is advised to wear corrective lenses and this study can be used to prevent misinterpretation of VEP findings.
EFFECTS OF AEROBIC TRAINING ON LIPID PROFILE
Introduction: Aerobic exercises like walking, running, cycling scores for ordinary persons to improve their physical fitness and health. The aim of this study is to investigate the effects of tread mill exercise and ergometer cycling on lipid profile. Materials and methods: This study includes 80 subjects, of these 40 subjects were in control group (Group A) and 40 subjects were in aerobic training (study group). The study group is further subdivided into Group B consists of 20 subjects who underwent treadmill training and Group C consists of 20 subjects who underwent cycling. Study subjects underwent aerobic training of moderate intensity for 12 weeks, five days in a week, one hour per day on tread mill for Group B individuals and five days in a week, fifteen minutes per day on the cycle for Group C individuals. Results: Students paired 't' test was used to test statistical significance between pre and post tests for each group. Results showed significant reduction in Total Cholesterol, Triglycerides, Very low density lipoprotein, Low Density Lipoprotein, Total Cholesterol/High Density Lipoprotein ratio, Low Density Lipoprotien/High Density Lipoprotein ratio and elevation of High Density Lipoprotein in post test compared to pre test with p value of < 0.05 in aerobic training group. Control group, showed no significant improvement in post test compared to pre test with p value of > 0.05. Conclusion: The study concluded that aerobic exercise has a definite favourable impact on lipid profile, compared to sedentary individuals. Thus both treadmill and bicycle ergometer can be recommended for the favourable improvement on lipid profile
A RARE CASE OF ENDOBRONCHIAL MALIGNANT PERIPHERAL NERVE SHEATH TUMOR
Malignant schwannoma also called Malignant peripheral nerve sheath tumor (MPNST), is a rare and aggressive sarcoma that arises from the nerve sheath, with an incidence of 0.001%. It usually arises from peripheral nerves or somatic soft tissues. We describe a rare case of endobronchial Malignant peripheral nerve sheath tumor in a middle aged female who presented with right middle and lower lobe collapse. The diagnosis was made from the history, clinical examination, radiological investigations and bronchoscopy. The patient was subjected to pneumonectomy and tracheoplasty.
EFFECT OF YOGASANA ON GLYCAEMIA AND INSULIN SENSITIVITY IN TYPE II DIABETES
Background: Globally Diabetes Mellitus is a major health problem. The prevalence of NIDDM accounts for 85 % of Diabetes worldwide. This study was conducted to establish the effectiveness of yoga on diabetic individuals. 30 Subjects in the age group of 30 - 60 years, with diabetes was taken for study. Fasting Blood sugar and fasting insulin levels were estimated. The subjects were taught few asanas, and asked to practice it for 4 weeks. At the end of four weeks, again the sugar and insulin levels estimated. This study proved that yogasanas can be considered for increasing insulin sensitivity to glucose.
EFFECT OF PACLITAXEL ALONG WITH WITHNIA SOMINIFERIA ON LACTATE DEHYDROGENASE ENZYME ACTIVITY CHANGES IN 7, 12 DI METHYL BENZ (A) ANTHRACENE INDUCED BREAST CANCER WISTARRATS
Background: The purpose of this study is to investigate the changes in the levels of lactate dehydrogenase enzyme (LDH) activity and efficacy of combination of paclitaxel along with Withnia Sominiferia against breast cancer in experimental animals. Breast cancer is the commonest cancer among women in all developed countries (except Japan) as well as in North Africa, South America, and southeastern and western Asia. While the incidence of breast cancer appears to be increasing, mortality rates are now declining in at least some western countries. Breast cancer ranks third when both the sexes are considered together and is clearly a significant global public health problem. Methods: Breast cancer was induced in rats by 7, 12 Di methyl benz(a) anthracene (DMBA) at the dosage of 20mgs dissolved in 0.5ml sunflower oil and administered into experimental animals for 28 weeks. In this study, we demonstrated that combination of paclitaxel and withania somnifera revert the changes in the rats from lethal dose of DMBA within 30 days. Results: All the isoenzymes LDH1, LDH5 were observed in cancer bearing animals. Expression of these isoenzymes were found be reduced in paclitaxel and Withania somnifera treated animals. Conclusions: The treatment with combination of paclitaxel and withania somnifera effectively reduced LDH enzyme activity levels. So, from the obtained results it is concluded that paclitaxel and withania somnifera is capable of restoring the breast architecture.
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A CLINICAL STUDY OF A SUPERFICIAL DERMATOPHYTIC INFECTION IN KANCHIPURAM
Background: Dermatophytic infection is the most commonly seen skin disease in our dermatology OPD. Dermatophytic infection is commonly seen in trophic and subtrophic regions like India. This study is done to find out the commonest type of Dermatophyte seen in our dermatology OPD and the organism causing the dermatophytic infection. Aims and objectives:1) To find out the commonest clinical type of Dermatophytic infection in our dermatology Out Patient department.2) To correlate between the KOH mount, Culture positivity and Dermatophytic infection. Materials and methods: 50 patients of dermatophytosis attending the dermatology outpatient department of Meenakshi Medical College and Research Institute from January 2013 to January 2014 are included in our study.KOH mount and fungal culture was done for all the patients with Dermaphytic infection. RESULTS: Male are more commonly affected than females in dermatophytosis. 21-30 years age group is commonly affected although patients of all age can be affected by dermatophytosis. Tinea corporis is the commonest clinical type T.rubrum is the commonest etiological agent isolated.
A BIOCHEMICAL PROFILE ON PATIENTS WITH XANTHELASMA PALPEBRARUM: A CLINICAL STUDY
Background: Xanthelasma palpebrarum refers to fat deposition that occurs on eyelids and inner canthi. It may be associated with certain systemic conditions. Aims: 1.To find the relationship between Xanthelasma palpebrarum and biochemical lipid profile. 2. To find the relationship between the parameters of age, sex, comorbid illness, with Xanthelasma palpebrarum. Methods: In this type of Case control study, 50 cases with Xanthelasma palpebrarum and 50 healthy individuals were selected. All cases and controls underwent clinical examination and fasting lipid profile study. Result: Total cholesterol levels were increased in 64% (32 cases) as compared to 19 controls (38%) with p=0.009, making it highly significant. LDL cholesterol levels were increased in 41 cases (82%) as compared to 30 controls (60%) making it statistically significant with a p value of 0.015. No significant relationship was observed with respect to other cholesterol parameters. Conclusion: This study shows that there is a significant elevation in total cholesterol and LDL cholesterol in Xanthelasma palpebrarum patients as compared to controls, thus making lipid profile compulsory for all patients with Xanthelasma.
STUDY OF ONSET AND DURATION OF SEDATIVE EFFECT OF CLONIDINE WITH VARIOUS ROUTES OF ADMINISTRATION IN WISTAR ALBINO RATS
Background: The aim of present study is to demonstrate the sedative effect of Clonidine, along with its onset &duration of action with oral, intraperitoneal & intravenous routes of administration in Wistar Albino rats. Two well established methods were adopted these include actophotometer and rota rod. In the present study rapid onset of sedation is observed with intravenous administration of Clonidine where as longer duration of sedative effect is observed with intraperitoneal administration.
SEPARATION OF CANCER PROTEINS USING POLYACRYLAMIDE GEL ELECTROPHORESIS
Background: Normally the cancer development occurs due to unregulated body metabolisms, Mutations, uncontrolled cell growth, some of the proteins also involved in development of cancer disease. The variation also occurs in the amount of albumins and globulins from a normal cell to cancerous cell. The present work is conducted to know the amounts of serum albumins and globulins in the cancer patients, for this, we selected positive cancer samples from patients admitted in Warangal district hospital and subjected to Organic solution precipitation and salt precipitation. Subsequently these precipitated protein samples were analyzed by SDS Polyacrylamide gel electrophoresis, and different bands of albumin and globulin seen with different concentrations in a densitometer.
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A COMPARATIVE STUDY OF IQ LEVELS IN MYOPIC CHILDREN WITH NON-MYOPIC CHILDREN BETWEEN THE AGE GROUP OF 8-15 YEARS
Introduction: In Andhrapradesh state the prevalence of myopia is elevated with increasing age and it is more in the urban area. Myopia is increased in highly intelligent population as compared to the general population. Materials & Methods: This is a comparative study of Intelligent Quotient levels in myopic students in the age group of 08-15 years. The study was conducted in (n=300) aged between 08-15 years. Case group involves 50 students, those were already diagnosed as myopic were selected and 50 students of same age group were considered as control. Results: Intelligent Quotient levels of myopic students were statistically significantly higher than the non-myopic students.
A COMPARATIVE STUDY OF THE AMPLITUDE AND FREQUENCY OF EMG ON THE EFFECT OF MUSCLES IN SELECTED YOGA TRAINED SUBJECTS AND IN SUBJECTS EXCLUSIVELY PERFORMING ABDOMINAL CRUNCHES
Background: Electromyography refers to recording of action potentials of muscle fibers firing singly or in groups near the needle electrode in a muscle. Yoga and yoga-related training have often been touted as providing good muscle stretching and relaxation, as well as being beneficial for overall stress management. As life style changes have caused numerous cardiac and metabolic disorders which have increased the mortality and morbidity rate, this study will highlight the implications of these exercises and also identify the electrical activity of these abdominal and truncal muscles with regard to frequency and amplitude and make us to understand the physiological concepts and provide advice on the benefits of these exercises. Our aim was to perform comparative study of the amplitude and frequency of EMG on the effect of muscles in selected yoga trained subjects and in subjects exclusively performing abdominal crunches. Methods: The present study was carried out with the prior approval of Human Ethical Committee of Meenakshi University. The participants of this study were first year students of Meenakshi Medical College (n=20). Electrical activity of these abdominal and truncal muscles with regard to frequency and amplitude were tested. Results: Abdominal muscle are essential for the purpose of this study was to determine and compare the rectus abdominus and external oblique while the subjects performed various abdominal exercise intended to target to specific muscle sites. With respect to the rectus abdominus, and external oblique, no significant differences were found (P > 0.05). However, there was a trend toward somewhat higher EMG amplitudes in the left rectus abdominus compared with the rectus abdominus breathing exercise. Conclusions: In conclusion by use of abdominal crunch appears to be effective in recruiting the abdominal muscles and also safe in not excessively activating the unwanted hip flexor muscles. Our findings suggested that little difference be detected in the EMG activity of different rectus abdominus portions. However, our results illustrate the unconformity between the usual practice and scientific based observations and highlight the greater importance of exercise intensity to activate both muscle portions.
A COMPARATIVE STUDY ON EFFECT OF PRANAYAMAAND SURYANAMASKAR YOGIC EXERCISE ON STATICSPIROMETRY VALUES IN NORMAL YOUNG HEALTHY INDIVIDUALS
Introduction: Yogic practices can be considered to be a very good exercise for maintaining proper health and also has a profound effect on the lung functions of an individual. They are also used as psycho-physiological stimuli to increase the physiological functions and human performance. Materials & Methods: The present study was conducted on 60 male medical students in first year M.B.B.S, who came voluntarily as subjects for the project with written consent. Their age ranged between 18-24 years. All the participants were given training for 15 days by a certified yoga teacher and were allowed to practice pranayama and suryanamaskar exercise for one hour everyday in the evening for a duration of six months. Five types of pranayama namely; Bhastrika pranayama, Anuloma vilom pranayama, Bhramari pranayama and Pranava pranayama were chosen for this study. Various static spirometry tests were done to measure the Tidal volume (TV), Slow vital capacity (SVC), Inspiratory reserve volume (IRV), Expiratory reserve volume (ERV). Pulmonary function test was performed in all the participants using computerized pulmonary testing machine (Helios- 401, RMS).Results: The obtained data was analyzed for statistical significance using SPSS software of 22.0 version followed by students t test and p<0.005 was considered the level of significance. There was significant increase in all these variables(p<0.001) in the study group after six months of yoga. Conclusion: From this study we concluded that, the practice of yoga can be advocated to improve respiratory efficiency for healthy individuals as well as an alternative therapy or as adjunct to conventional therapy in respiratory diseases and improve the anesthetic fitness for cardiothoracic surgery.
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