STUDY OF ONSET AND DURATION OF SEDATIVE EFFECT OF CLONIDINE WITH VARIOUS ROUTES OF ADMINISTRATION IN WISTAR ALBINO RATS

Abstract

Background: The aim of present study is to demonstrate the sedative effect of Clonidine, along with its onset &duration of action with oral, intraperitoneal & intravenous routes of administration in Wistar Albino rats. Two well established methods were adopted these include actophotometer and rota rod. In the present study rapid onset of sedation is observed with intravenous administration of Clonidine where as longer duration of sedative effect is observed with intraperitoneal administration.