STUDY ON GLYCEMIC STATUS IN SIBLINGS OF DIABETIC PARENTS

Abstract

Introduction: As per Indian council of medical research survey, incidence of diabetes in 1975 was around 2.1% which increased to 4.5% by 1990 and with the present trend is likely to reach around 6.8% in this millennium. Offspring of patients with Non insulin depended diabetes mellitus have a 40-60% chance of developing type 2 diabetes and increased frequency of impaired glucose tolerance. The siblings of diabetic parents are at high risk than siblings of non diabetic parents. The glycemic status plays a crucial role and it is a good indicator to alert the offspring’s of diabetic parents. Materials & Methods: The study was carried in department of Biochemistry on 30 control cases (23 Males 07 Females) of siblings of non diabetic parents (Group I) and 60 cases (42 Males, 18 Females) of siblings of diabetic parents (Group II) of same aged group. The glycemic status of both groups is studied by estimating the Glucose tolerance test and glycated haemoglobin. Results: Siblings of diabetic parents were further divided into two groups, normal glucose tolerance group and impaired glucose tolerance group. The Body mass index, fasting blood glucose, peak blood glucose and glycated haemoglobin levels were shown significant difference in siblings of diabetic parents with impaired glucose tolerance.